Structure of PDB 2tod Chain C

Receptor sequence
>2todC (length=353) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
GDPFFVADLGDIVRKHETWKKCLPRVTPFYAVACNDDWRVLGTLAALGTG
FDCASNTEIQRVRGIGVPPEKIIYANPCKQISHIRYARDSGVDVMTFDCV
DELEKVAKTHPKAKMVLRISTLSVKFGAKVEDCRFILEQAKKLNIDVTGV
SFHVGSGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGGFPGTRDA
PLKFEEIAGVINNALEKHFPPDLKLTIVAEPGRYYVASAFTLAVNVIAKK
VTPAQSFMYYVNDGVYGSFNCILYDHAVVRPLPQREPIPNEKLYPSSVWG
PTCDGLDQIVERYYLPEMQVGEWLLFEDMGAYTVVGTSSFNGFQSPTIYY
VVS
3D structure
PDB2tod X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
ChainC
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A69 H197 E274
Catalytic site (residue number reindexed from 1) A33 H153 E230
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DMO C C360 D361 F397 C303 D304 F340
BS02 PLP C H197 S200 G236 G237 E274 G276 R277 Y389 H153 S156 G192 G193 E230 G232 R233 Y332
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0033387 putrescine biosynthetic process from ornithine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2tod, PDBe:2tod, PDBj:2tod
PDBsum2tod
PubMed10563800
UniProtP07805|DCOR_TRYBB Ornithine decarboxylase

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