Structure of PDB 2ql9 Chain C

Receptor sequence
>2ql9C (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGF
DVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGV
TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ
3D structure
PDB2ql9 Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis.
ChainC
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G385 V386 H444 G445 C486
Catalytic site (residue number reindexed from 1) G29 V30 H88 G89 C130
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R387 H444 Q484 C486 R31 H88 Q128 C130
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2ql9, PDBe:2ql9, PDBj:2ql9
PDBsum2ql9
PubMed17697120
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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