Structure of PDB 2qe0 Chain C

Receptor sequence
>2qe0C (length=474) Species: 1309 (Streptococcus mutans) [Search protein sequence]
TKQYKNYVNGEWKLSENEIKIYEPASGAELGSVPAMSTEEVDYVYASAKK
AQPAWRALSYIERAAYLHKVADILMRDKEKIGAILSKEVAKGYKSAVSEV
VRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAVVRREPVGLVLAIS
PFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGLPAG
VFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAGMRPIMLAL
GGKDSAIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELV
EKIREKVLALTIGNPEDDADITPLIDTKSADYVEGLINDANDKGATALTE
IKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIEISNKS
EYGLQASIFTNDFPRAFGIAEQLEVGTVHINNKTQRGTDNFPFLGAKKSG
AGIQGVKYSIEAMTTVKSVVFDIK
3D structure
PDB2qe0 The First Crystal Structure of a Thioacylenzyme Intermediate in the ALDH Family: New Coenzyme Conformation and Relevance to Catalysis
ChainC
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N154 K177 A250 C284 E377 Q455
Catalytic site (residue number reindexed from 1) N153 K176 A249 C283 E376 Q454
Enzyme Commision number 1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G3H C R103 Y155 R283 C284 T285 Q436 R437 R102 Y154 R282 C283 T284 Q435 R436
BS02 NAP C I150 S151 P152 F153 K177 P178 P179 T180 G210 G214 F228 G230 S231 I234 Y333 E377 F379 I149 S150 P151 F152 K176 P177 P178 T179 G209 G213 F227 G229 S230 I233 Y332 E376 F378
Gene Ontology
Molecular Function
GO:0008886 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity
GO:0008911 lactaldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0047100 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity

View graph for
Molecular Function
External links
PDB RCSB:2qe0, PDBe:2qe0, PDBj:2qe0
PDBsum2qe0
PubMed16503652
UniProtQ59931|GAPN_STRMU NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (Gene Name=gapN)

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