Structure of PDB 2pzy Chain C

Receptor sequence
>2pzyC (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFA
LKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECL
DGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPEN
LLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVI
MYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI
RNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDV
KEEMTSA
3D structure
PDB2pzy The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
ChainC
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D145 K147 E149 N150 D166
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU C L70 G71 L72 G73 A91 M138 C140 L141 E190 N191 L193 T206 D207 L29 G30 L31 G32 A50 M97 C99 L100 E149 N150 L152 T165 D166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2pzy, PDBe:2pzy, PDBj:2pzy
PDBsum2pzy
PubMed17576063
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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