Structure of PDB 2pt9 Chain C

Receptor sequence
>2pt9C (length=280) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KWFSEFSIMWPGQAFSLKIKKILYETKSKYQNVLVFESTTYGKVLVLDGV
IQLTEKDEFAYHEMMTHVPMTVSKEPKNVLVVGGGDGGIIRELCKYKSVE
NIDICEIDETVIEVSKIYFKNISCGYEDKRVNVFIEDASKFLENVTNTYD
VIIVDSSDPIGPAETLFNQNFYEKIYNALKPNGYCVAQCESLWIHVGTIK
NMIGYAKKLFKKVEYANISIPTYPCGCIGILCCSKTDTGLTKPNKKLESK
EFADLKYYNYENHSAAFKLPAFLLKEIENI
3D structure
PDB2pt9 Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M C Q92 G123 D126 E146 I147 V151 D177 D195 P202 A203 Q52 G83 D86 E106 I107 V111 D137 D155 P162 A163
BS02 2MH C V90 Q92 S196 D198 Y263 I268 V50 Q52 S156 D158 Y223 I228 MOAD: ic50=35uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0008295 spermidine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pt9, PDBe:2pt9, PDBj:2pt9
PDBsum2pt9
PubMed17822713
UniProtQ8II73

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