Structure of PDB 2prz Chain C

Receptor sequence
>2przC (length=215) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
LEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLFNTGKLLSNLA
TAYAIAIIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAF
NRKEAGIIVGSALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSII
ALDRQEVVSTDDKEGLSATQTVSKKYGIPVLSIVSLIHIITYLEGRITAE
EKSKIEQYLQTYGAS
3D structure
PDB2prz Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase.
ChainC
Resolution1.895 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.10: orotate phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OMP C L28 K29 F37 F38 D132 V133 T135 A136 G137 T138 A139 R163 L25 K26 F34 F35 D123 V124 T126 A127 G128 T129 A130 R154
Gene Ontology
Molecular Function
GO:0004588 orotate phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2prz, PDBe:2prz, PDBj:2prz
PDBsum2prz
PubMed18020427
UniProtP13298|PYRE_YEAST Orotate phosphoribosyltransferase 1 (Gene Name=URA5)

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