Structure of PDB 2pmv Chain C

Receptor sequence
>2pmvC (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
SCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMNLAGAYNLKAQKL
LTYQLMSSDNNDLTIGHLGLTIMALTSSCRDPGDKVSILQRQMENWAPSS
PNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGA
MATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIY
STGLAMQALSVTPEPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPS
LKGKTYLDVPQVTCSPDTSASNITVIYTINNQLRGVELLFNETINVSVKS
GSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFL
SGVTPLNEGVADYIPFNHEHITANFTQY
3D structure
PDB2pmv Crystal structure of human intrinsic factor: Cobalamin complex at 2.6-A resolution
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B12 C G72 H73 Y115 D153 D204 Y206 S207 Q252 S347 W348 G349 L350 V351 V352 Y367 W368 Q369 F370 P376 L377 N378 E379 G380 Y399 G66 H67 Y109 D147 D198 Y200 S201 Q246 S326 W327 G328 L329 V330 V331 Y346 W347 Q348 F349 P355 L356 N357 E358 G359 Y378
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031419 cobalamin binding
GO:0140355 cargo receptor ligand activity
Biological Process
GO:0006824 cobalt ion transport
GO:0015889 cobalamin transport
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005902 microvillus
GO:0016324 apical plasma membrane
GO:0043202 lysosomal lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pmv, PDBe:2pmv, PDBj:2pmv
PDBsum2pmv
PubMed17954916
UniProtP27352|IF_HUMAN Cobalamin binding intrinsic factor (Gene Name=CBLIF)

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