Structure of PDB 2pj1 Chain C

Receptor sequence
>2pj1C (length=305) Species: 9823 (Sus scrofa) [Search protein sequence]
TGHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGK
PGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLD
FYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTT
GASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMIL
YPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGG
SDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNY
VLGHL
3D structure
PDB2pj1 Structures of potent selective peptide mimetics bound to carboxypeptidase B.
ChainC
Resolution1.64 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H65 E68 R123 H193 E267
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H69 E72 H196 H65 E68 H193
BS02 578 C H69 R71 E72 R127 N144 R145 T164 H196 S197 Y198 L203 S207 Y248 D255 E270 H65 R67 E68 R123 N140 R141 T160 H193 S194 Y195 L200 S204 Y245 D252 E267 MOAD: ic50=9.7nM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2pj1, PDBe:2pj1, PDBj:2pj1
PDBsum2pj1
PubMed18219114
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

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