Structure of PDB 2pj0 Chain C

Receptor sequence
>2pj0C (length=304) Species: 9823 (Sus scrofa) [Search protein sequence]
GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKP
GPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDF
YVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTG
ASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILY
PYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGS
DDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYV
LGHL
3D structure
PDB2pj0 Structures of potent selective peptide mimetics bound to carboxypeptidase B.
ChainC
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H64 E67 R122 H192 E266
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H69 E72 H196 H64 E67 H192
BS02 922 C H69 E72 R127 N144 R145 T164 H196 S197 Y198 L203 S207 Y248 D255 E270 H64 E67 R122 N139 R140 T159 H192 S193 Y194 L199 S203 Y244 D251 E266 MOAD: ic50=8.1nM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2pj0, PDBe:2pj0, PDBj:2pj0
PDBsum2pj0
PubMed18219114
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

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