Structure of PDB 2p6g Chain C

Receptor sequence

>2p6gC (length=435) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

DKAKKLENLLKLLQLNNHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISD
KPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFF
NWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINF
LCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYT
HRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDID
QVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPD
GKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKAT
KALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFL
NFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML

3D structure

PDB

2p6g Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.

Chain

Resolution

3.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1)	N149 F150 L151 T185 L435
Enzyme Commision number	2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MYA	C	H38 F40 W41 I168 N169 L171 C172 V173 R178 S179 R181 T183 I187 T191 V194 H201 A202 Y204 I208 L210 F425	H18 F20 W21 I148 N149 L151 C152 V153 R158 S159 R161 T163 I167 T171 V174 H181 A182 Y184 I188 L190 F405
BS02	3LP	C	F113 Y115 Y219 H221 F234 L332 Y349 N397 D417 G418 L455	F93 Y95 Y199 H201 F214 L312 Y329 N377 D397 G398 L435

Gene Ontology

	Molecular Function
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
GO:0016746	acyltransferase activity

	Biological Process
GO:0006499	N-terminal protein myristoylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2p6g, PDBe:2p6g, PDBj:2p6g
PDBsum	2p6g
PubMed	17513302
UniProt	P14743\|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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