Structure of PDB 2p6e Chain C

Receptor sequence
>2p6eC (length=446) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EDKAKKLENLLKLLQLNNDDTSKFTQEDHKFWRTQPVKDFDEKVVEEGPI
DKPKTPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDA
GFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVR
GKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIV
LPAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTA
GLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQ
VIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADF
QFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLD
DLKFGPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
3D structure
PDB2p6e Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region.
ChainC
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1) N160 F161 L162 T196 L446
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA C Q29 H38 F40 W41 Y103 V166 I168 N169 L171 V173 R178 S179 R181 T183 I187 I190 T191 V194 H201 Y204 I208 L210 F425 Q26 H29 F31 W32 Y94 V157 I159 N160 L162 V164 R169 S170 R172 T174 I178 I181 T182 V185 H192 Y195 I199 L201 F416
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2p6e, PDBe:2p6e, PDBj:2p6e
PDBsum2p6e
PubMed17513302
UniProtP14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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