Structure of PDB 2oip Chain C

Receptor sequence

>2oipC (length=514) Species: 237895 (Cryptosporidium hominis)

EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNAL
IMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLM
NDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPE
TFLPVYMSQTFCTKNISYDFMIFEKQEKCDPARGQLKSIDDTVDLLGEIF
GIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENR
TGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNGNH
LIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMH
DDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQ
YYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELA
IFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELI
GYYPYPTIKMDMAV

3D structure

• PDB: 2oip Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis
• Chain: C
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UMP	C	R257 Y342 C402 H403 Q422 R423 S424 D426 N434 H464 Y466	R250 Y335 C395 H396 Q415 R416 S417 D419 N427 H457 Y459
BS02	MTX	C	V9 V10 A11 L25 F36 S37 L67 R70 C113	V7 V8 A9 L23 F34 S35 L65 R68 C111
BS03	NDP	C	A11 I19 G20 G23 Q24 L25 G55 R56 K57 T58 I75 S76 S77 G115 S117 T145	A9 I17 G18 G21 Q22 L23 G53 R54 K55 T56 I73 S74 S75 G113 S115 T143
BS04	UMP	C	R382 R383	R375 R376

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sat Nov 16 09:57:27 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '2oip', asym_id = 'C', title = 'Nonconserved residues Ala287 and Ser290 of the C...se domain facilitate its rapid rate of catalysis '

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='2oip', asym_id='C', title='Nonconserved residues Ala287 and Ser290 of the C...se domain facilitate its rapid rate of catalysis ')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004146,0004799,0006231,0006730,0016741,0046654', uniprot = '', pdbid = '2oip', asym_id = 'C'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004146,0004799,0006231,0006730,0016741,0046654', uniprot='', pdbid='2oip', asym_id='C')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>