Structure of PDB 2ofw Chain C

Receptor sequence
>2ofwC (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
RATNVTYQAHHVSRNKRGQVVGTRGGFRGCTIWLTGLSGAGKTTVSMALE
EYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADA
GLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGL
YKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLNER
DILP
3D structure
PDB2ofw Elucidation of the Active Conformation of the APS-Kinase Domain of Human PAPS Synthetase 1.
ChainC
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADX C D89 R92 F101 R106 N109 F131 I132 S133 P134 L173 G184 F185 T186 D66 R69 F78 R83 N86 F108 I109 S110 P111 L150 G161 F162 T163 MOAD: Ki=17uM
BS02 ADX C G62 G64 K65 T66 T67 V68 R168 T204 V209 G39 G41 K42 T43 T44 V45 R145 T181 V186 MOAD: Ki=17uM
Gene Ontology
Molecular Function
GO:0004020 adenylylsulfate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000103 sulfate assimilation

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Molecular Function
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Biological Process
External links
PDB RCSB:2ofw, PDBe:2ofw, PDBj:2ofw
PDBsum2ofw
PubMed17276460
UniProtO43252|PAPS1_HUMAN Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (Gene Name=PAPSS1)

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