Structure of PDB 2ns8 Chain C

Receptor sequence
>2ns8C (length=206) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRAL
LDALAIEMLDRHHTHFSPLEGESWQDFLRNNAKSFRNALLSHRDGAKVHL
GTRPTEKQYETLENQLAFLTQQGFSLENALYALSAVGHFTLGSVLEDQEH
QVAKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLHGLESLIRGFEVQL
TALLQI
3D structure
PDB2ns8 How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
ChainC
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L60 R104 P105 L113 Q116 L117 L134 S135 H139 L59 R103 P104 L112 Q115 L116 L133 S134 H138
BS02 peptide C E147 D148 H151 K155 E156 P161 M166 I174 F177 G181 E146 D147 H150 K154 E155 P160 M165 I173 F176 G180
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2ns8, PDBe:2ns8, PDBj:2ns8
PDBsum2ns8
PubMed17374541
UniProtP04483|TETR2_ECOLX Tetracycline repressor protein class B from transposon Tn10 (Gene Name=tetR)

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