Structure of PDB 2j87 Chain C

Receptor sequence
>2j87C (length=163) Species: 10245 (Vaccinia virus) [Search protein sequence]
GHIQLIIGPMFSGKSTELIRRVRRYQIAQYKCVTIKYSNDDKNNFEALEA
TKLCDVLQSITDFSVIGIDEGQFFPDIVEFCERMANEGKIVIVAALDGTF
QRKPFNNILNLLILSEMVVKLTAVCMKCFKEASFSKRLGEETEIEIIGGN
DMYQSVCRKCYVG
3D structure
PDB2j87 Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design.
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTP C M13 F14 S15 G16 K17 S18 D82 E83 F86 L109 F113 I157 E158 I159 I160 G161 Y166 M10 F11 S12 G13 K14 S15 D69 E70 F73 L96 F100 I144 E145 I146 I147 G148 Y153 PDBbind-CN: -logKd/Ki=4.85,IC50=14uM
BS02 ZN C C138 C141 C170 C125 C128 C157
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0016310 phosphorylation
GO:0046104 thymidine metabolic process
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2j87, PDBe:2j87, PDBj:2j87
PDBsum2j87
PubMed17062140
UniProtO57203|KITH_VACCA Thymidine kinase (Gene Name=OPG101)

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