Structure of PDB 2j4e Chain C

Receptor sequence

>2j4eC (length=194) Species: 9606 (Homo sapiens)

SMAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEP
DEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEG
LHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDF
GWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLA

3D structure

• PDB: 2j4e Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T.
• Chain: C
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 3.6.1.9: nucleotide diphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ITT	C	T14 G15 N16 K19 E44 K56 D72 T73 K89 F149 W151 D152 K172 H177 R178	T15 G16 N17 K20 E45 K57 D73 T74 K90 F150 W152 D153 K173 H178 R179

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016787 hydrolase activity
• GO:0035870 dITP diphosphatase activity
• GO:0036220 ITP diphosphatase activity
• GO:0036222 XTP diphosphatase activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:0047429 nucleoside triphosphate diphosphatase activity

Biological Process

• GO:0006193 ITP catabolic process
• GO:0009117 nucleotide metabolic process
• GO:0009143 nucleoside triphosphate catabolic process
• GO:0009204 deoxyribonucleoside triphosphate catabolic process
• GO:0051276 chromosome organization

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:2j4e, PDBe:2j4e, PDBj:2j4e
• PDBsum: 2j4e
• PubMed: 17138556
• UniProt: Q9BY32|ITPA_HUMAN Inosine triphosphate pyrophosphatase (Gene Name=ITPA)