Structure of PDB 2ixc Chain C

Receptor sequence
>2ixcC (length=198) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNC
SVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDS
VLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATD
PTLAVDWPLVDGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGE
3D structure
PDB2ixc Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
ChainC
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H62 K72 Y132 D171
Catalytic site (residue number reindexed from 1) H62 K72 Y132 D171
Enzyme Commision number 5.1.3.13: dTDP-4-dehydrorhamnose 3,5-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TRH C R59 H62 K72 H119 Y132 Y138 R59 H62 K72 H119 Y132 Y138
BS02 TRH C H19 R23 F26 E28 H19 R23 F26 E28
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO:0016853 isomerase activity
Biological Process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ixc, PDBe:2ixc, PDBj:2ixc
PDBsum2ixc
PubMed17046787
UniProtP9WH11|RMLC_MYCTU dTDP-4-dehydrorhamnose 3,5-epimerase (Gene Name=rmlC)

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