Structure of PDB 2i7c Chain C

Receptor sequence
>2i7cC (length=281) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KKWFSEFSIMWPGQAFSLKIKKILYETKSKYQNVLVFESTTYGKVLVLDG
VIQLTEKDEFAYHEMMTHVPMTVSKEPKNVLVVGGGDGGIIRELCKYKSV
ENIDICEIDETVIEVSKIYFKNISCGYEDKRVNVFIEDASKFLENVTNTY
DVIIVDSSDPIGPAETLFNQNFYEKIYNALKPNGYCVAQCESLWIHVGTI
KNMIGYAKKLFKKVEYANISIPTYPCGCIGILCCSKTDTGLTKPNKKLES
KEFADLKYYNYENHSAAFKLPAFLLKEIENI
3D structure
PDB2i7c Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.
ChainC
Resolution1.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AAT C Q54 G85 G86 D88 E108 I109 D139 A140 D157 S158 S159 D160 P164 A165 Y225 Q53 G84 G85 D87 E107 I108 D138 A139 D156 S157 S158 D159 P163 A164 Y224 MOAD: ic50=8.5uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:2i7c, PDBe:2i7c, PDBj:2i7c
PDBsum2i7c
PubMed17822713
UniProtQ8II73

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