Structure of PDB 2i47 Chain C

Receptor sequence
>2i47C (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
MKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQ
FSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYY
SPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECF
QERS
3D structure
PDB2i47 Identification of potent and selective TACE inhibitors via the S1 pocket.
ChainC
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H405 H409 H415 H185 H189 H195
BS02 KGY C T347 L348 G349 E398 L401 V402 H405 E406 H409 H415 P437 A439 V440 T127 L128 G129 E178 L181 V182 H185 E186 H189 H195 P217 A219 V220 MOAD: ic50=2.2nM
BindingDB: IC50=2.2nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2i47, PDBe:2i47, PDBj:2i47
PDBsum2i47
PubMed17064892
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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