Structure of PDB 2hz4 Chain C

Receptor sequence
>2hz4C (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
KWEMERTDITMKHKLGEVYEGVWKKYTVAVKTLKDTMEVEEFLKEAAVMK
EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLL
YMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGD
TYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYP
GIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ
AFETMFQES
3D structure
PDB2hz4 Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D122 A124 R126 N127 D140 P161
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4ST C F497 Q498 S500 F256 Q257 S259
BS02 4ST C W235 Q300 W2 Q59
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:2hz4, PDBe:2hz4, PDBj:2hz4
PDBsum2hz4
PubMed17164530
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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