Structure of PDB 2gzw Chain C

Receptor sequence
>2gzwC (length=200) Species: 562 (Escherichia coli) [Search protein sequence]
TDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEG
KEMILSYLNQGDFIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLI
QVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDA
MTHPDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVY
3D structure
PDB2gzw Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 A resolution
ChainC
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP C V49 L61 G71 E72 L73 R82 S83 A84 R123 V43 L55 G65 E66 L67 R76 S77 A78 R117
BS02 CMP C K57 E58 Q170 G173 Q174 G177 C178 S179 R180 K51 E52 Q164 G167 Q168 G171 C172 S173 R174
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003680 minor groove of adenine-thymine-rich DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0008301 DNA binding, bending
GO:0030552 cAMP binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0045013 carbon catabolite repression of transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol
GO:0032993 protein-DNA complex

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Biological Process
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Cellular Component
External links
PDB RCSB:2gzw, PDBe:2gzw, PDBj:2gzw
PDBsum2gzw
PubMed
UniProtP0ACJ8|CRP_ECOLI DNA-binding transcriptional dual regulator CRP (Gene Name=crp)

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