Structure of PDB 2fum Chain C

Receptor sequence
>2fumC (length=254) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSF
YLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRD
IVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAV
KVMDFAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSV
AYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADLV
RVHN
3D structure
PDB2fum The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria
ChainC
Resolution2.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156
Catalytic site (residue number reindexed from 1) D136 K138 A140 N141 D154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MIX C G18 A38 M92 V95 G97 M155 G16 A36 M90 V93 G95 M153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2fum, PDBe:2fum, PDBj:2fum
PDBsum2fum
PubMed16674948
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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