Structure of PDB 2ffl Chain C

Receptor sequence
>2fflC (length=718) Species: 5741 (Giardia intestinalis) [Search protein sequence]
AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFE
AGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPR
FISNPPQFATLAFLPLLSPTSPLDLRALMVTAQLMCDAKRLSDELSASLH
GRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHL
RAADLPLVAAVRLDDLKDHQIPAPDDLAPKLRFLPPELCLLLPDEFDLIR
VQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQ
GRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDA
SVGTLVELKMELVRNEALNYLVQTLGLPQLAEFSKSKTWADMYEEIVGSI
FTGPNGIYGCEEFLAKTLMSPEHSKTACPDAVTKASKRVCMGEAGAHEFR
SLVDYACEQGISVFCSSRVSTMFLERLRDIPAEDMLDWYRLGIQFSHRSG
LSVSVIDIMTHLARGLWLGSPGFYVEQPPTIPVLYIYHRSVQCPVLYGSL
TTGPVASKVLALYEKILASGGSKHIAAQTVSRSLAVPIPSGTIPFLIRLL
QIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETN
SVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEE
AAGAFVREHVLPQVVADA
3D structure
PDB2ffl Structural Basis of Double-Stranded RNA Processing by Dicer
ChainC
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN C E649 D720 E723 E613 D684 E687
BS02 MN C E336 D404 E407 E328 D391 E394
BS03 MN C D653 E684 D617 E648
BS04 MN C E336 E673 E328 E637
BS05 MN C E491 D495 E475 D479
BS06 MN C H668 P669 T670 H632 P633 T634
BS07 MN C F355 P356 D357 F347 P348 D349
BS08 MN C N202 H204 N197 H199
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing

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Molecular Function
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Biological Process
External links
PDB RCSB:2ffl, PDBe:2ffl, PDBj:2ffl
PDBsum2ffl
PubMed16410517
UniProtA8BQJ3|DCL_GIAIC Endoribonuclease Dicer-like (Gene Name=GL50803_103887)

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