Structure of PDB 2fah Chain C

Receptor sequence
>2fahC (length=608) Species: 9031 (Gallus gallus) [Search protein sequence]
LSTSLSALPAAARDFVEEAVRLCRPREVLLCDGSEEEGKELLRGLQDDGV
LHPLPKYDNCWLARTDPRDVARVESKTVLVTPEQSDAVPPPPPSGGPPQL
GNWMSPNAFQAAVQERFPGCMAGRPLYVIPFSMGPPTSPLAKLGVQVTDS
PYVVLSMRIMTRVGPAVLQRLDDDFVRCLHSVGRPLPLTEPLVSSWPCDP
SRVLVAHIPSERRIVSFGSGYGGNSLLGKKCFALRIASRMAQQQGWLAEH
MLILGVTSPSGEKRYMAAAFPSACGKTNLAMMTPSLPGWRIHCVGDDIAW
MKFDDEGRLRAINPERGFFGVAPGTSSRTNPNAMATIARNTIFTNVGLRS
DGGVYWDGLDEPTEPGVTYTSWLGKPWKHGDPEPCAHPNSRFCAPADQCP
IMDPRWDDPEGVPIDAIIFGGRRPRGVPLVVEAFGWRHGVFMGSAMRSEA
TAAAEHKGGRLMHDPFAMRPFFGYNAGRYLEHWLSTGLRSNARLPRLFHV
NWFLRDNEGRFVWPGFGHNARVLAWIFGRIQGRDTARPTPIGWVPKEGDL
DLGGLPGVDYSQLFPMEKGFWEEECRQLREYYGENFGADLPRDVMAELEG
LEERVRKM
3D structure
PDB2fah Structural Insights into the Mechanism of PEPCK Catalysis
ChainC
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R105 Y254 K263 H283 S305 C307 D330 R424
Catalytic site (residue number reindexed from 1) R72 Y221 K230 H250 S272 C274 D297 R391
Enzyme Commision number 4.1.1.32: phosphoenolpyruvate carboxykinase (GTP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TQY C F467 E630 R637 F434 E597 R604
BS02 GDP C A306 C307 G308 K309 T310 N311 P356 R455 F536 F544 F549 A273 C274 G275 K276 T277 N278 P323 R422 F503 F511 F516
BS03 MN C K263 H283 D330 K230 H250 D297
BS04 MN C T310 G353 V354 T277 G320 V321
Gene Ontology
Molecular Function
GO:0004611 phosphoenolpyruvate carboxykinase activity
GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 GTP binding
GO:0017076 purine nucleotide binding
Biological Process
GO:0006094 gluconeogenesis

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Molecular Function
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Biological Process
External links
PDB RCSB:2fah, PDBe:2fah, PDBj:2fah
PDBsum2fah
PubMed16819824
UniProtP21642|PCKGM_CHICK Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (Gene Name=PCK2)

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