Structure of PDB 2f8x Chain C

Receptor sequence
>2f8xC (length=424) Species: 9606 (Homo sapiens) [Search protein sequence]
RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVY
LMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCT
AKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSL
KNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHL
LDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALL
DADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND
GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELT
GQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQV
PVTLVRNDGIIYSTSLTFTYTPEP
3D structure
PDB2f8x Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
ChainC
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C K50 R51 F52 K152 R178 S181 T183 K40 R41 F42 K142 R168 S171 T173
BS02 dna C K44 Y46 S151 K152 K157 R180 Q182 K34 Y36 S141 K142 K147 R170 Q172
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2f8x, PDBe:2f8x, PDBj:2f8x
PDBsum2f8x
PubMed16530044
UniProtQ06330|SUH_HUMAN Recombining binding protein suppressor of hairless (Gene Name=RBPJ)

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