Structure of PDB 2f55 Chain C

Receptor sequence
>2f55C (length=432) [Search protein sequence]
PPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFG
AYMSKAHGIDPNIRTGVRTITTGGSITYSTYGKFLADGGCSGGAYDIIIC
DECHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEI
GLSNNGEIPFYGKAIPIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAV
AYYRGLDVSVIPPIGDVVVVATDALFTGDFDSVIDCNTCVTQTVDFSLDP
TFTIETTTVPQDAVSRSQRRGRTGRGRSGIYRFVTPGERPSGMFDSSVLC
ECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFTGLTHI
DAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTL
HGPTPLLYRLGAVQNEVILTHPITKYIMACMS
3D structure
PDB2f55 Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C V232 G255 T269 G271 K272 R393 W501 V43 G66 T80 G82 K83 R204 W309
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:2f55, PDBe:2f55, PDBj:2f55
PDBsum2f55
PubMed16306038
UniProtO92972|POLG_HCVJ4 Genome polyprotein

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