Structure of PDB 2eg5 Chain C

Receptor sequence
>2eg5C (length=344) Species: 49390 (Coffea canephora) [Search protein sequence]
GDTSYAKNSAYNQLVLAKVKPVLEQCVRELLRANLPNINKCIKVADLGCA
SGPNTLLTVRDIVQSIDKVGQLERPTIQIFLNDLFPNDFNSVFKLLPSFY
RKLEKENGRKIGSCLIGAMPGSFYSRLFPEESMHFLHSCYCLQWLSQVPS
GLVTELIGTNKGSIYSSKASRLPVQKAYLDQFTKDFTTFLRIHSEELFSH
GRMLLTCICKGVELDARNAIDLLEMAINDLVVEGHLEEEKLDSFNLPVYI
PSAEEVKCIVEEEGSFEILYLETFKVLYDAGFSHIKAEYVASSVRAVYEP
ILASHFGEAIIPDIFHRFAKHAAKVLPLGKGFYNNLIISLAKKP
3D structure
PDB2eg5 The structure of two N-methyltransferases from the caffeine biosynthetic pathway
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.158: 7-methylxanthosine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C Y18 G61 A63 D101 L102 G139 S140 F141 C157 C159 Y5 G48 A50 D83 L84 G121 S122 F123 C139 C141
BS02 XTS C N21 S22 Y24 N25 Y158 Q161 S316 V320 Y321 Y356 N8 S9 Y11 N12 Y140 Q143 S293 V297 Y298 Y333
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009820 alkaloid metabolic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2eg5, PDBe:2eg5, PDBj:2eg5
PDBsum2eg5
PubMed17434991
UniProtA4GE69|XMT1_COFCA 7-methylxanthosine synthase 1 (Gene Name=XMT1)

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