Structure of PDB 2e49 Chain C

Receptor sequence

>2e49C (length=340) Species: 9606 (Homo sapiens) [Search protein sequence]

MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAG
LWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHE
AIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTE
RLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRG
QIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSEL
NNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLS

3D structure

PDB

2e49 Structural basis of d-DOPA oxidation by d-amino acid oxidase: Alternative pathway for dopamine biosynthesis.

Chain

Resolution

3.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	G2313 T2317
Catalytic site (residue number reindexed from 1)	G313 T317
Enzyme Commision number	1.4.3.3: D-amino-acid oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	C	V2010 A2036 D2037 R2038 T2043 T2044 T2045 V2047 A2048 G2050 L2051 V2164 T2182 G2183 L2189 G2281 P2284 G2312 G2313 Y2314 G2315 L2316 T2317	V10 A36 D37 R38 T43 T44 T45 V47 A48 G50 L51 V164 T182 G183 L189 G281 P284 G312 G313 Y314 G315 L316 T317
BS02	MH6	C	Y2224 Y2228 R2283 G2313	Y224 Y228 R283 G313

Gene Ontology

	Molecular Function
GO:0003884	D-amino-acid oxidase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0042802	identical protein binding
GO:0071949	FAD binding

	Biological Process
GO:0006562	proline catabolic process
GO:0007586	digestion
GO:0019478	D-amino acid catabolic process
GO:0036088	D-serine catabolic process
GO:0042416	dopamine biosynthetic process
GO:0046416	D-amino acid metabolic process
GO:0055130	D-alanine catabolic process
GO:0070178	D-serine metabolic process
GO:0070945	neutrophil-mediated killing of gram-negative bacterium

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0042995	cell projection
GO:0045202	synapse
GO:0048786	presynaptic active zone

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2e49, PDBe:2e49, PDBj:2e49
PDBsum	2e49
PubMed	17303072
UniProt	P14920\|OXDA_HUMAN D-amino-acid oxidase (Gene Name=DAO)

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