Structure of PDB 2c21 Chain C

Receptor sequence
>2c21C (length=139) Species: 5664 (Leishmania major) [Search protein sequence]
SRRMLHTMIRVGDLDRSIKFYTERLGMKVLRKWDVPEDKYTLVFLGYGPE
MSSTVLELTYNYGVTSYKHDEAYGHIAIGVEDVKELVADMRKHDVPIDYE
DESGFMAFVVDPDGYYIELLNEKTMMEKAEADMKEQGTA
3D structure
PDB2c21 Specificity of the Trypanothione-Dependent Leishmania Major Glyoxalase I: Structure and Biochemical Comparison with the Human Enzyme.
ChainC
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H8 E59 H77 E120
Catalytic site (residue number reindexed from 1) H6 E57 H75 E118
Enzyme Commision number 4.4.1.5: lactoylglutathione lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NI C H8 E59 H6 E57
BS02 NI C H77 E120 H75 E118
Gene Ontology
Molecular Function
GO:0004462 lactoylglutathione lyase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2c21, PDBe:2c21, PDBj:2c21
PDBsum2c21
PubMed16430697
UniProtQ68RJ8

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