Structure of PDB 2c0a Chain C

Receptor sequence
>2c0aC (length=213) Species: 562 (Escherichia coli) [Search protein sequence]
MKNWKTSAESILTTGPVVPVIVVKKLEHAVPMAKALVAGGVRVLNVTLRT
ECAVDAIRAIAKEVPEAIVGAGTVLNPQQLAEVTEAGAQFAISPGLTEPL
LKAATEGTIPLIPGISTVSELMLGMDYGLKEFKFFPAEANGGVKALQAIA
GPFSQVRFCPTGGISPANYRDYLALKSVLCIGGSWLVPADALEAGDYDRI
TKLAREAVEGAKL
3D structure
PDB2c0a Mechanism of the Class I Kdpg Aldolase.
ChainC
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N45 R49 K133
Catalytic site (residue number reindexed from 1) N45 R49 K133
Enzyme Commision number 4.1.2.14: 2-dehydro-3-deoxy-phosphogluconate aldolase.
4.1.3.16: 4-hydroxy-2-oxoglutarate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 C G162 G183 S184 G162 G183 S184
Gene Ontology
Molecular Function
GO:0008675 2-dehydro-3-deoxy-phosphogluconate aldolase activity
GO:0008700 (R,S)-4-hydroxy-2-oxoglutarate aldolase activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0016829 lyase activity
GO:0016833 oxo-acid-lyase activity
GO:0042802 identical protein binding
GO:0106009 (4S)-4-hydroxy-2-oxoglutarate aldolase activity
Biological Process
GO:0009255 Entner-Doudoroff pathway through 6-phosphogluconate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2c0a, PDBe:2c0a, PDBj:2c0a
PDBsum2c0a
PubMed16403639
UniProtP0A955|ALKH_ECOLI KHG/KDPG aldolase (Gene Name=eda)

[Back to BioLiP]