Structure of PDB 2b8t Chain C

Receptor sequence
>2b8tC (length=199) Species: 134821 (Ureaplasma parvum) [Search protein sequence]
IGWIEFITGPMFAGKTAELIRRLHRLEYADVKYLVFKPKIDSRTGTSLPS
VEVESAPEILNYIMSNSFNDETKVIGIDEVQFFDDRICEVANILAENGFV
VIISGLDKNFKGEPFGPIAKLFTYADKITKLTAICNECGAEATHSLRKID
GKHADYNDDIVKIGCQEFYSAVCRHHHKVPNRPYLNSNSEEFIKFFKNK
3D structure
PDB2b8t Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C153 C156 C191 H194 C135 C138 C173 H176
BS02 THM C E97 F100 L124 N127 F128 F133 I178 V179 K180 G182 Y187 E79 F82 L106 N109 F110 F115 I160 V161 K162 G164 Y169
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0016310 phosphorylation
GO:0046104 thymidine metabolic process
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b8t, PDBe:2b8t, PDBj:2b8t
PDBsum2b8t
PubMed16336273
UniProtQ9PPP5|KITH_UREPA Thymidine kinase (Gene Name=tdk)

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