Structure of PDB 2b4g Chain C

Receptor sequence
>2b4gC (length=313) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
MSLKVNILGHEFSNPFMNAAGVLCTTEEDLRRMTESESGSLIGKSCTLAP
RTGNPEPRYFGLPLGSINSMGLPNLGVDFYLSYAAQTHDYSRKPLFLSMS
GLSVEESVEMVKKLVPITKEKGTILELNLSCPNVPGKPQVGYDFDTTRTY
LQKVSEAYGLPFGVKMPPYFDIAHFDMAAAVLNDFPLVKFITCVNSIGNG
LVIDPANETVVIKPKQGFGGLGGKYVLPTALANVNAFFRRCPDKLVFGCG
GVYSGEEAFLHILAGASMVQVGTALHDEGPIIFARLNKELQEIMTNKGYK
TLDEFRGRVKTMD
3D structure
PDB2b4g Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
ChainC
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K44 N68 L72 L127 C131 N133 V134 K165 V194
Catalytic site (residue number reindexed from 1) K44 N68 L72 L127 C131 N133 V134 K165 V194
Enzyme Commision number 1.3.98.1: dihydroorotate oxidase (fumarate).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN C A19 A20 G21 K44 S45 N68 M70 N128 K165 N195 G223 C249 G250 G251 G272 T273 A19 A20 G21 K44 S45 N68 M70 N128 K165 N195 G223 C249 G250 G251 G272 T273
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:1990663 dihydroorotate dehydrogenase (fumarate) activity
Biological Process
GO:0006106 fumarate metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0020015 glycosome
GO:0097014 ciliary plasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b4g, PDBe:2b4g, PDBj:2b4g
PDBsum2b4g
PubMed18312275
UniProtQ57U83|PYRD_TRYB2 Dihydroorotate dehydrogenase (fumarate) (Gene Name=Tb927.5.3830)

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