Structure of PDB 2ac0 Chain C

Receptor sequence
>2ac0C (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGG
MNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLR
3D structure
PDB2ac0 Structural Basis of DNA Recognition by p53 Tetramers
ChainC
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C S241 R248 R273 C275 A276 C277 R280 S146 R153 R178 C180 A181 C182 R185 PDBbind-CN: Kd=25nM
BS02 dna C A119 K120 S121 A24 K25 S26 PDBbind-CN: Kd=25nM
BS03 ZN C C176 H179 C238 C242 C81 H84 C143 C147
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ac0, PDBe:2ac0, PDBj:2ac0
PDBsum2ac0
PubMed16793544
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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