Structure of PDB 2a4r Chain C

Receptor sequence
>2a4rC (length=151) [Search protein sequence]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M
3D structure
PDB2a4r Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency.
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H29 D53 G109 S111
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C A111 V113 A83 V85
BS02 peptide C V29 G31 E32 V33 Q34 I35 V36 S37 R62 T63 I64 A65 P88 G90 V1 G3 E4 V5 Q6 I7 V8 S9 R34 T35 I36 A37 P60 G62
BS03 ZN C C97 C99 C145 C69 C71 C117
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2a4r, PDBe:2a4r, PDBj:2a4r
PDBsum2a4r
PubMed16112862
UniProtP27958|POLG_HCV77 Genome polyprotein

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