Structure of PDB 2a1t Chain C

Receptor sequence
>2a1tC (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWE
LGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPI
IIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEY
IINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQI
GRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPV
VAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELA
RMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNT
EYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
3D structure
PDB2a1t Stabilization of Non-productive Conformations Underpins Rapid Electron Transfer to Electron-transferring Flavoprotein
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V135 T136 T255 E376 R388
Catalytic site (residue number reindexed from 1) V127 T128 T247 E368 R380
Enzyme Commision number 1.3.8.7: medium-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C Y133 V135 T136 G141 S142 W166 I167 T168 I371 T378 Q380 Y125 V127 T128 G133 S134 W158 I159 T160 I363 T370 Q372
BS02 FAD C R281 T283 F284 L288 H291 I294 Q349 I350 G353 R273 T275 F276 L280 H283 I286 Q341 I342 G345
BS03 FAD C Q163 W166 Q155 W158
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity
Biological Process
GO:0001889 liver development
GO:0005978 glycogen biosynthetic process
GO:0006082 organic acid metabolic process
GO:0006111 regulation of gluconeogenesis
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0007507 heart development
GO:0009409 response to cold
GO:0009437 carnitine metabolic process
GO:0009791 post-embryonic development
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0042594 response to starvation
GO:0045329 carnitine biosynthetic process
GO:0051791 medium-chain fatty acid metabolic process
GO:0051793 medium-chain fatty acid catabolic process
GO:0055007 cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030424 axon
GO:0031966 mitochondrial membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2a1t, PDBe:2a1t, PDBj:2a1t
PDBsum2a1t
PubMed15975918
UniProtP11310|ACADM_HUMAN Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADM)

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