Structure of PDB 1zxn Chain C

Receptor sequence
>1zxnC (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFV
PGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV
EHKVEKMYVPALIFGQLLTSSNYDDKVTGGRNGYGAKLCNIFSTKFTVET
ASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSL
DKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKVIHEQ
VNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVK
KKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTC
QLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKK
3D structure
PDB1zxn Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase.
ChainC
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C N91 N95 I125 I141 F142 S148 S149 G161 G164 Y165 G166 A167 N63 N67 I97 I113 F114 S120 S121 G130 G133 Y134 G135 A136
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zxn, PDBe:1zxn, PDBj:1zxn
PDBsum1zxn
PubMed16100112
UniProtP11388|TOP2A_HUMAN DNA topoisomerase 2-alpha (Gene Name=TOP2A)

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