Structure of PDB 1z7e Chain C

Receptor sequence
>1z7eC (length=639) Species: 562 (Escherichia coli) [Search protein sequence]
MKTVVFAYHDMGCLGIEALLAAGYEISAIFTHTDGSVARLAAERGIPVYA
PDNVNHPLWVERIAQLSPDVIFSFYYRHLIYDEILQLAPAGAFNLHGSLL
PKYRGRAPLNWVLVNGETETGVTLHRMVKRADAGAIVAQLRIAIAPDDIA
ITLHHKLCHAARQLLEQTLPAIKHGNILEIAQRENEATCFGRRTPDDSFL
EWHKPASVLHNMVRAVADPWPGAFSYVGNQKFTVWSSRVHPHASKAQPGS
VISVAPLLIACGDGALEIVTGQAGDGITMQGSQLAQTLGLVQGSRLRRTR
VLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDAISRFLNHPHFHFVEG
DISIHSEWIEYHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRII
RYCVKYRKRIIFPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSK
QLLDRVIWAYGEKEGLQFTLFRPFNWMGPRLDNLNAARIGSSRAITQLIL
NLVEGSPIKLIDGGKQKRCFTDIRDGIEALYRIIENAGNRCDGEIINIGN
PENEASIEELGEMLLASFEKHPLRHHFPPFAGFRVVESSSYYGKGYQDVE
HRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLRTVDLT
3D structure
PDB1z7e Structure and Mechanism of ArnA: Conformational Change Implies Ordered Dehydrogenase Mechanism in Key Enzyme for Polymyxin Resistance
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H104 D140
Catalytic site (residue number reindexed from 1) H96 D132
Enzyme Commision number 1.1.1.305: UDP-glucuronic acid oxidase (UDP-4-keto-hexauronic acid decarboxylating).
2.1.2.13: UDP-4-amino-4-deoxy-L-arabinose formyltransferase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0016831 carboxy-lyase activity
GO:0042802 identical protein binding
GO:0048040 UDP-glucuronate decarboxylase activity
GO:0070403 NAD+ binding
GO:0099618 UDP-glucuronic acid dehydrogenase activity
GO:0099619 UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009245 lipid A biosynthetic process
GO:0033320 UDP-D-xylose biosynthetic process
GO:0046493 lipid A metabolic process
GO:0046677 response to antibiotic
GO:2001315 UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z7e, PDBe:1z7e, PDBj:1z7e
PDBsum1z7e
PubMed15939024
UniProtP77398|ARNA_ECOLI Bifunctional polymyxin resistance protein ArnA (Gene Name=arnA)

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