Structure of PDB 1z0k Chain C

Receptor sequence
>1z0kC (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
YDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGG
KYVKLQIWDTAGLERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLT
DARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALT
GEDVEEAFVQCARKILNK
3D structure
PDB1z0k Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
ChainC
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L67
Catalytic site (residue number reindexed from 1) L63
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S22 T40 S18 T36
BS02 GTP C A17 G18 T19 G20 K21 S22 C23 F33 S37 H39 T40 G66 N121 K122 D124 L125 S151 A152 L153 A13 G14 T15 G16 K17 S18 C19 F29 S33 H35 T36 G62 N117 K118 D120 L121 S147 A148 L149
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0032482 Rab protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1z0k, PDBe:1z0k, PDBj:1z0k
PDBsum1z0k
PubMed16034420
UniProtP20338|RAB4A_HUMAN Ras-related protein Rab-4A (Gene Name=RAB4A)

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