Structure of PDB 1y9a Chain C

Receptor sequence
>1y9aC (length=360) Species: 5759 (Entamoeba histolytica) [Search protein sequence]
MKGLAMLGIGRIGWIEKKIPECGPLDALVRPLALAPCTSDTHTVWAGAIG
DRHDMILGHEAVGQIVKVGSLVKRLKVGDKVIVPAITPDWGEEESQRGYP
MHSGGMLGGWKFSNFKDGVFSEVFHVNEADANLALLPRDIKPEDAVMLSD
MVTTGFHGAELANIKLGDTVCVIGIGPVGLMSVAGANHLGAGRIFAVGSR
KHCCDIALEYGATDIINYKNGDIVEQILKATDGKGVDKVVIAGGDVHTFA
QAVKMIKPGSDIGNVNYLGEGDNIDIPRSEWGVGMGHKHIHGGLTPGGRV
RMEKLASLISTGKLDTSKLITHRFEGLEKVEDALMLMKNKPADLIKPVVR
IHYDDEDTLH
3D structure
PDB1y9a Structure of alcohol dehydrogenase from Entamoeba histolytica.
ChainC
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C37 T38 S39 D89 E92 S95 S103 D150 T154 K346
Catalytic site (residue number reindexed from 1) C37 T38 S39 D89 E92 S95 S103 D150 T154 K346
Enzyme Commision number 1.1.1.80: isopropanol dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C37 H59 D150 C37 H59 D150
BS02 CAC C S39 H59 W110 D150 S39 H59 W110 D150
BS03 ZN C D51 H53 D51 H53
BS04 ACT C P24 G69 S70 P24 G69 S70
BS05 EDO C G98 M101 H157 G98 M101 H157
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050009 isopropanol dehydrogenase (NADP+) activity
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1y9a, PDBe:1y9a, PDBj:1y9a
PDBsum1y9a
PubMed16627948
UniProtP35630|ADH1_ENTH1 NADP-dependent isopropanol dehydrogenase (Gene Name=ADH1)

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