Structure of PDB 1y10 Chain C

Receptor sequence
>1y10C (length=363) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
NIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVG
DDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAA
ARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATEL
DIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLP
GARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIK
TIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAG
DWFGSPVNVASRVTGVARPGAVLVADSVREALGDADGFQWSFAGPRRLRG
IRGDVRLFRVRRG
3D structure
PDB1y10 The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C G264 D265 G253 D254
Gene Ontology
Molecular Function
GO:0004016 adenylate cyclase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0010855 adenylate cyclase inhibitor activity
GO:0016829 lyase activity
GO:0030145 manganese ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009268 response to pH
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1y10, PDBe:1y10, PDBj:1y10
PDBsum1y10
PubMed15890882
UniProtP9WMU9|Y1264_MYCTU pH-sensitive adenylate cyclase Rv1264 (Gene Name=Rv1264)

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