Structure of PDB 1xka Chain C

Receptor sequence
>1xkaC (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF
RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY
VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT
GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTR
3D structure
PDB1xka Structural basis for chemical inhibition of human blood coagulation factor Xa.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G193 S195 G196
Catalytic site (residue number reindexed from 1) G183 S185 G186
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D70 N72 Q75 E76 E77 E80 D56 N58 Q61 E62 E63 E66
BS02 4PP C T98 Y99 F174 D189 A190 Q192 S195 V213 W215 G216 G218 T84 Y85 F162 D179 A180 Q182 S185 V203 W205 G206 G208 MOAD: Ki=131nM
PDBbind-CN: -logKd/Ki=6.88,Ki=131nM
BindingDB: IC50=270nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1xka, PDBe:1xka, PDBj:1xka
PDBsum1xka
PubMed9618463
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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