Structure of PDB 1wnt Chain C

Receptor sequence
>1wntC (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRE
CPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAF
DRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYC
STKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTM
LNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC
3D structure
PDB1wnt Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G18 S136 H146 Y149 K153
Catalytic site (residue number reindexed from 1) G18 S136 H146 Y149 K153
Enzyme Commision number 1.1.1.10: L-xylulose reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C G14 G16 K17 I19 S38 R39 T40 V59 L61 N83 A85 V134 Y149 K153 T180 V181 V182 T184 M186 G187 G14 G16 K17 I19 S38 R39 T40 V59 L61 N83 A85 V134 Y149 K153 T180 V181 V182 T184 M186 G187
Gene Ontology
Molecular Function
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0042802 identical protein binding
GO:0050038 L-xylulose reductase (NADPH) activity
Biological Process
GO:0005997 xylulose metabolic process
GO:0006006 glucose metabolic process
GO:0006739 NADP metabolic process
GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate
GO:0042732 D-xylose metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005903 brush border
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1wnt, PDBe:1wnt, PDBj:1wnt
PDBsum1wnt
PubMed15906319
UniProtQ7Z4W1|DCXR_HUMAN L-xylulose reductase (Gene Name=DCXR)

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