BioLiP

PDB

1w0x Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine.

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

BS01

OLO

I10 A31 F82 L83 Q85 Q131 L134

I10 A31 F75 L76 Q78 Q124 L127

PDBbind-CN: -logKd/Ki=5.30,IC50=5uM
BindingDB: IC50=7000nM

Molecular Function

GO:0000287

magnesium ion binding

GO:0004672

protein kinase activity

GO:0004674

protein serine/threonine kinase activity

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

protein binding

ATP binding

kinase activity

protein domain specific binding

GO:0030332

cyclin binding

GO:0035173

histone kinase activity

GO:0046872

metal ion binding

GO:0097472

cyclin-dependent protein kinase activity

GO:0106310

protein serine kinase activity

	Biological Process
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006338	chromatin remodeling
GO:0006351	DNA-templated transcription
GO:0006468	protein phosphorylation
GO:0006813	potassium ion transport
GO:0007099	centriole replication
GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007346	regulation of mitotic cell cycle
GO:0008284	positive regulation of cell population proliferation
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0010468	regulation of gene expression
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0031453	positive regulation of heterochromatin formation
GO:0031571	mitotic G1 DNA damage checkpoint signaling
GO:0032298	positive regulation of DNA-templated DNA replication initiation
GO:0043247	telomere maintenance in response to DNA damage
GO:0043687	post-translational protein modification
GO:0045740	positive regulation of DNA replication
GO:0045893	positive regulation of DNA-templated transcription
GO:0051298	centrosome duplication
GO:0051301	cell division
GO:0051321	meiotic cell cycle
GO:0071732	cellular response to nitric oxide
GO:0090398	cellular senescence
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process

Biological Process

GO:0000082

G1/S transition of mitotic cell cycle

GO:0000086

G2/M transition of mitotic cell cycle

GO:0000122

negative regulation of transcription by RNA polymerase II

DNA replication

DNA repair

chromatin remodeling

DNA-templated transcription

GO:0006468

protein phosphorylation

GO:0006813

potassium ion transport

GO:0007099

centriole replication

GO:0007165

signal transduction

GO:0007265

Ras protein signal transduction

GO:0007346

regulation of mitotic cell cycle

GO:0008284

positive regulation of cell population proliferation

GO:0010389

regulation of G2/M transition of mitotic cell cycle

GO:0010468

regulation of gene expression

GO:0016310

phosphorylation

GO:0018105

peptidyl-serine phosphorylation

GO:0031453

positive regulation of heterochromatin formation

GO:0031571

mitotic G1 DNA damage checkpoint signaling

GO:0032298

positive regulation of DNA-templated DNA replication initiation

GO:0043247

telomere maintenance in response to DNA damage

GO:0043687

post-translational protein modification

GO:0045740

positive regulation of DNA replication

GO:0045893

positive regulation of DNA-templated transcription

GO:0051298

centrosome duplication

GO:0051301

cell division

GO:0051321

meiotic cell cycle

GO:0071732

cellular response to nitric oxide

GO:0090398

cellular senescence

GO:1905784

regulation of anaphase-promoting complex-dependent catabolic process

	Cellular Component
GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0000781	chromosome, telomeric region
GO:0000793	condensed chromosome
GO:0000805	X chromosome
GO:0000806	Y chromosome
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005667	transcription regulator complex
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015030	Cajal body
GO:0097123	cyclin A1-CDK2 complex
GO:0097124	cyclin A2-CDK2 complex
GO:0097134	cyclin E1-CDK2 complex
GO:0097135	cyclin E2-CDK2 complex

Cellular Component

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

GO:0000781

chromosome, telomeric region

condensed chromosome

X chromosome

Y chromosome