Structure of PDB 1v8b Chain C

Receptor sequence

>1v8bC (length=476) Species: 36329 (Plasmodium falciparum 3D7)

NKSKVKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCL
HMTVECALLIETLQKLGAQIRWCSCNIYSTADYAAAAVSTLENVTVFAWK
NETLEEYWWCVESALTWGDGDDNGPDMIVDDGGDATLLVHKGVEYEKLYE
EKNILPDPEKAKNEEERCFLTLLKNSILKNPKKWTNIAKKIIGVSEETTT
GVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCRHSLPDGLMRATDF
LISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEGFNV
VTLDEIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVN
ELFNYKGIHIENVKPQVDRITLPNGNKIIVLARGRLLNLGCATGHPAFVM
SFSFCNQTFAQLDLWQNKDTNKYENKVYLLPKHLDEKVALYHLKKLNASL
TELDDNQCQFLGVNKSGPFKSNEYRY

3D structure

• PDB: 1v8b Crystal Structure of S-Adenosyl-l-Homocysteine Hydrolase from the Human Malaria Parasite Plasmodium falciparum
• Chain: C
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H54 S77 S82 D134 E200 N225 K230 D234 N235 C239 H345 H398 S406 Q410
• Catalytic site (residue number reindexed from 1): H51 S74 S79 D131 E197 N222 K227 D231 N232 C236 H342 H395 S403 Q407
• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	C	T201 T202 T203 N235 G264 G266 D267 V268 T286 E287 I288 T320 G321 N322 I343 G344 H345 N391 H398	T198 T199 T200 N232 G261 G263 D264 V265 T283 E284 I285 T317 G318 N319 I340 G341 H342 N388 H395
BS02	ADN	C	H54 T56 E58 D134 E200 T201 D234 H398 M403	H51 T53 E55 D131 E197 T198 D231 H395 M400
BS03	NAD	C	K473 Y477	K470 Y474

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1v8b, PDBe:1v8b, PDBj:1v8b
• PDBsum: 1v8b
• PubMed: 15476817
• UniProt: P50250|SAHH_PLAF7 Adenosylhomocysteinase (Gene Name=PFE1050w)