Structure of PDB 1u2z Chain C

Receptor sequence
>1u2zC (length=385) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SSTFVDWNGPCLRLQYPLFDIEYLRSHEIYSGTPIQSISLRTTTAKLQSI
LFSNYMEEYKVDFKRSTAIYNPMSEIGKLIEYSCLVFLPSPYAEQLKETI
LPDLNASFDNSDTKGFVNAINLYNKMIREIPRQRIIDHLETIDKIPRSFI
HDFLHIVYTRSIHPQANKLKHYKAFSNYVYGELLPNFLSDVYQQCQLKKG
DTFMDLGSGVGNCVVQAALECGCALSFGCEIMDDASDLTILQYEELKKRC
KLYGMRLNNVEFSLKKSFVDNNRVAELIPQCDVILVNNFLFDEDLNKKVE
KILQTAKVGCKIISLKSLRSLTYQINFYNVENIFNRLKVQRYDLKEDSVS
WTHSGGEYYISTVMEDVDESLFSPAARRTPVKYTR
3D structure
PDB1u2z Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.360: [histone H3]-lysine(79) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C Y370 G373 L375 D397 G399 C405 E422 I423 S459 F460 Y178 G181 L183 D205 G207 C213 E230 I231 S267 F268
Gene Ontology
Molecular Function
GO:0031151 histone H3K79 methyltransferase activity
GO:0042393 histone binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006281 DNA repair
GO:0031509 subtelomeric heterochromatin formation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u2z, PDBe:1u2z, PDBj:1u2z
PDBsum1u2z
PubMed15292170
UniProtQ04089|DOT1_YEAST Histone-lysine N-methyltransferase, H3 lysine-79 specific (Gene Name=DOT1)

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