Structure of PDB 1tzk Chain C

Receptor sequence

>1tzkC (length=335) Species: 74568 (Pseudomonas sp. ACP)

MNLQRFPRYPLTFGPTPIQPLARLSKHLGGKVHLYAKREDCNSGLAFGGN
KTRKLEYLIPEALAQGCDTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQE
NWVNYSDAVYDRVGNIQMSRILGADVRLVPDGFDIGFRRSWEDALESVRA
AGGKPYAIPAGCSDHPLGGLGFVGFAEEVRAQEAEKFDYVVVCSVTGSTQ
AGMVVGFAADGRADRVIGVDASAKPAQTREQITRIARQTAEKVGLERDIM
RADVVLDERFAGPEYGLPNEGTLEAIRLCARTEGMLTDPVYEGKSMHGMI
EMVRNGEFPEGSRVLYAHLGGVPALNGYSFIFRDG

3D structure

• PDB: 1tzk Structural Analysis of Pseudomonas 1-Aminocyclopropane-1-carboxylate Deaminase Complexes: Insight into the Mechanism of a Unique Pyridoxal-5'-phosphate Dependent Cyclopropane Ring-Opening Reaction
• Chain: C
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K51 Y268 Y294
• Catalytic site (residue number reindexed from 1): K51 Y265 Y291
• Enzyme Commision number: 3.5.99.7: 1-aminocyclopropane-1-carboxylate deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	C	N50 K51 K54 N79 C196 S197 T199 G200 T202 Y294 E295 L322 G323 G324	N50 K51 K54 N79 C193 S194 T196 G197 T199 Y291 E292 L319 G320 G321
BS02	2KT	C	K51 S78 N79 Q80 Y294	K51 S78 N79 Q80 Y291

Gene Ontology

Molecular Function

• GO:0008660 1-aminocyclopropane-1-carboxylate deaminase activity
• GO:0016787 hydrolase activity
• GO:0019148 D-cysteine desulfhydrase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009310 amine catabolic process
• GO:0018871 1-aminocyclopropane-1-carboxylate metabolic process

External links

• PDB: RCSB:1tzk, PDBe:1tzk, PDBj:1tzk
• PDBsum: 1tzk
• PubMed: 15491139
• UniProt: Q00740|1A1D_PSEUD 1-aminocyclopropane-1-carboxylate deaminase (Gene Name=acdS)