Structure of PDB 1txt Chain C

Receptor sequence
>1txtC (length=387) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
TIGIDKINFYVPKYYVDMAKLAEARQVDPNKFLIGIGQTEMAVSPVNQDI
VSMGANAAKDIITDEDKKKIGMVIVATESAVDAAKAAAVQIHNLLGIQPF
ARCFEMKEACYAATPAIQLAKDYLATRPNEKVLVIATDTARYGLNSGGEP
TQGAGAVAMVIAHNPSILALNEDAVAYTEDVYDFWRPTGHKYPLVDGALS
KDAYIRSFQQSWNEYAKRQGKSLADFASLCFHVPFTKMGKKALESIIDNA
DETTQERLRSGYEDAVDYNRYVGNIYTGSLYLSLISLLENRDLQAGETIG
LFSYGSGSVVEFYSATLVEGYKDHLDQAAHKALLNNRTEVSVDAYETFFK
RFDDVEFDEEQDAVHEDRHIFYLSNIENNVREYHRPE
3D structure
PDB1txt Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism
ChainC
Resolution2.501 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.3.5: Transferred entry: 2.3.3.10.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAA C D29 N31 K32 G36 A111 Y143 G148 T152 F185 S201 P235 F236 M239 K242 D28 N30 K31 G35 A110 Y142 G147 T151 F184 S200 P234 F235 M238 K241
Gene Ontology
Molecular Function
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1txt, PDBe:1txt, PDBj:1txt
PDBsum1txt
PubMed15292254
UniProtQ9FD87

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