Structure of PDB 1tu3 Chain C

Receptor sequence
>1tu3C (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]
CQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTT
VKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKEL
QRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSM
NVNEIFMAIAKKLPKN
3D structure
PDB1tu3 Structural basis of Rab5-Rabaptin5 interaction in endocytosis
ChainC
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S34 T52 S16 T34
BS02 GNP C S29 A30 G32 K33 S34 S35 F45 H46 E47 Q49 S51 T52 G78 N133 K134 D136 S163 A164 K165 S11 A12 G14 K15 S16 S17 F27 H28 E29 Q31 S33 T34 G60 N115 K116 D118 S145 A146 K147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:1tu3, PDBe:1tu3, PDBj:1tu3
PDBsum1tu3
PubMed15378032
UniProtP20339|RAB5A_HUMAN Ras-related protein Rab-5A (Gene Name=RAB5A)

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