Structure of PDB 1tnd Chain C

Receptor sequence
>1tndC (length=316) Species: 9913 (Bos taurus) [Search protein sequence]
ARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQS
ILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRL
WKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVK
TTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAY
DMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKK
AHLSICFPDYNGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQ
NVKFVFDAVTDIIIKE
3D structure
PDB1tnd The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.
ChainC
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E39 T44 R174 D196 Q200
Catalytic site (residue number reindexed from 1) E13 T18 R148 D170 Q174
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S43 T177 S17 T151
BS02 GSP C G38 E39 S40 G41 K42 S43 T44 D146 L171 R172 S173 R174 T177 G198 N265 K266 D268 C321 A322 T323 G12 E13 S14 G15 K16 S17 T18 D120 L145 R146 S147 R148 T151 G172 N239 K240 D242 C295 A296 T297
Gene Ontology
Molecular Function
GO:0000035 acyl binding
GO:0001664 G protein-coupled receptor binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019003 GDP binding
GO:0019901 protein kinase binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007601 visual perception
GO:0007602 phototransduction
GO:0007603 phototransduction, visible light
GO:0009416 response to light stimulus
GO:0050908 detection of light stimulus involved in visual perception
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0001917 photoreceptor inner segment
GO:0005737 cytoplasm
GO:0005834 heterotrimeric G-protein complex
GO:0016020 membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane
GO:0097648 G protein-coupled receptor complex

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Cellular Component
External links
PDB RCSB:1tnd, PDBe:1tnd, PDBj:1tnd
PDBsum1tnd
PubMed8259210
UniProtP04695|GNAT1_BOVIN Guanine nucleotide-binding protein G(t) subunit alpha-1 (Gene Name=GNAT1)

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