Structure of PDB 1tjj Chain C

Receptor sequence
>1tjjC (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
MSSFSWDNCDEGKDPAVIRSLTLEPDPIVVPGNVTLSVVGSTSVPLSSPL
KVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLR
TYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKR
LGCIKIAASLKGI
3D structure
PDB1tjj Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PFS C L57 L130 Y139 R140 I141 I157 L161 L56 L129 Y138 R139 I140 I156 L160
BS02 LPE C V18 I19 V53 Y116 S143 C154 I155 V17 I18 V52 Y115 S142 C153 I154
Gene Ontology
Molecular Function
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0016004 phospholipase activator activity
GO:0016787 hydrolase activity
GO:0030290 sphingolipid activator protein activity
GO:0032428 beta-N-acetylgalactosaminidase activity
Biological Process
GO:0001573 ganglioside metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006689 ganglioside catabolic process
GO:0006869 lipid transport
GO:0007611 learning or memory
GO:0009313 oligosaccharide catabolic process
GO:0019915 lipid storage
GO:0046479 glycosphingolipid catabolic process
GO:0050877 nervous system process
GO:0050885 neuromuscular process controlling balance
GO:0051651 maintenance of location in cell
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0035578 azurophil granule lumen
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1tjj, PDBe:1tjj, PDBj:1tjj
PDBsum1tjj
PubMed15327957
UniProtP17900|SAP3_HUMAN Ganglioside GM2 activator (Gene Name=GM2A)

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